Services


MSF Services

We provide mass spectrometry based analysis in fee-for-service format for the Texas A&M University Department of Chemistry, other departments throughout the university, and to researchers outside the university.

Our services include, but are not limited to mass analysis of small molecules including identification and structural elucidation, and mass analysis of macromolecules such polymers, dendrimers, and oligonucleotides. We have summarized our services as follows:

Small and Macromolecule analysis

Analyses of small and macromolecules, which involve determination or confirmation of synthesized products, using low or high resolution mass spectrometry, are considered routine analysis.  The following analyses methods are applicable for routine small molecule analysis.

Electron Ionization and Chemical ionization-GCMS

  • Low resolution mass measurements of volatile and thermally stable nonpolar compounds
  • Coupled to gas chromatographic separation
  • Mass range less than 1000 Da
  • Sample introduction: standard GC sample injection, headspacer, and direct probe
  • Service available-daily

Atmospheric pressure chemical ionization (APCI) MS and MSn

  • Low resolution mass measurement for polar and relatively nonpolar compounds such as for determination of nominal mass
  • Mass range: less than 2000
  • Fragmentation to MSn capability
    • Fragmentation can provide structural confirmation
  • Sample introduction; direct infusion or LC
  • Service available-daily

ESI-MS and ESI/MS/MS

  • Low resolution mass measurement for determination of nominal mass
  • High resolution accurate mass measurement (mass accuracy less than 5 ppm)
    *Note for this service unit mass should be determined first.
  • High resolution tandem mass (MS/MS) analysis for structure elucidation
  • Sample introduction: direct infusion
  • Service available-daily

MALDI-TOF-MS

  • Nominal mass measurements
  • High resolution mass measurements up to 5000 Da
  • Service available daily.

Macromolecule

Analyses by low resolution mass spectrometry for most synthesized macromolecules such as polymers, dendrimers, and intact proteins is considered routine analysis. The following methods are available:

MALDI-TOF-MS

  • Low resolution unit mass measurements
  • Service available-daily

ESI-MS

  • Samples can be run using traditional electrospray or nanospray ionization.